Placeholder image of a protein
Icon representing a puzzle

1065: 90 Residue Monomer Design: Zero Cysteines

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
March 18, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for It's over 9000! 21. It's over 9000! 1 pt. 7,102
  2. Avatar for Crunching Family 22. Crunching Family 1 pt. 7,074
  3. Avatar for Chem233W15 23. Chem233W15 1 pt. 7,036
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 5,606
  5. Avatar for Natural Abilities 25. Natural Abilities 1 pt. 4,170
  6. Avatar for Minions of TWIS 26. Minions of TWIS 1 pt. 0
  7. Avatar for Window Group 27. Window Group 1 pt. 0
  8. Avatar for SETI.Germany 28. SETI.Germany 1 pt. 0
  9. Avatar for Team China 29. Team China 1 pt. 0

  1. Avatar for MurloW
    1. MurloW Lv 1
    100 pts. 10,787
  2. Avatar for retiredmichael 2. retiredmichael Lv 1 98 pts. 10,748
  3. Avatar for eusair 3. eusair Lv 1 96 pts. 10,730
  4. Avatar for dembones 4. dembones Lv 1 94 pts. 10,683
  5. Avatar for karstenw 5. karstenw Lv 1 92 pts. 10,679
  6. Avatar for santex 6. santex Lv 1 90 pts. 10,653
  7. Avatar for Museka 7. Museka Lv 1 88 pts. 10,648
  8. Avatar for Galaxie 8. Galaxie Lv 1 86 pts. 10,634
  9. Avatar for g_b 9. g_b Lv 1 84 pts. 10,623
  10. Avatar for nicobul 10. nicobul Lv 1 82 pts. 10,616

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.