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1065: 90 Residue Monomer Design: Zero Cysteines

Closed since about 11 years ago

Intermediate Overall Design

Summary


Created
March 18, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for It's over 9000! 21. It's over 9000! 1 pt. 7,102
  2. Avatar for Crunching Family 22. Crunching Family 1 pt. 7,074
  3. Avatar for Chem233W15 23. Chem233W15 1 pt. 7,036
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 5,606
  5. Avatar for Natural Abilities 25. Natural Abilities 1 pt. 4,170
  6. Avatar for Minions of TWIS 26. Minions of TWIS 1 pt. 0
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  8. Avatar for SETI.Germany 28. SETI.Germany 1 pt. 0
  9. Avatar for Team China 29. Team China 1 pt. 0

  1. Avatar for hpaege 41. hpaege Lv 1 39 pts. 9,967
  2. Avatar for gurra66 42. gurra66 Lv 1 38 pts. 9,947
  3. Avatar for pmdpmd 43. pmdpmd Lv 1 37 pts. 9,937
  4. Avatar for ManVsYard 44. ManVsYard Lv 1 36 pts. 9,884
  5. Avatar for stomjoh 45. stomjoh Lv 1 35 pts. 9,880
  6. Avatar for Bletchley Park 46. Bletchley Park Lv 1 34 pts. 9,852
  7. Avatar for georg137 47. georg137 Lv 1 33 pts. 9,849
  8. Avatar for nemo7731 48. nemo7731 Lv 1 32 pts. 9,771
  9. Avatar for gloverd 49. gloverd Lv 1 32 pts. 9,759
  10. Avatar for SIW 50. SIW Lv 1 31 pts. 9,504

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.