1078: 90 Residue Monomer Design: More Sheets!

Closed since almost 11 years ago

Summary

• Created: April 20, 2015
• Expires: April 27, 2015 at 23:00 UTC
• Max points: 100

Description

In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Go Science 100 pts. 10,731
• 2. Beta Folders 81 pts. 10,690
• 3. Anthropic Dreams 64 pts. 10,672
• 4. Contenders 50 pts. 10,505
• 5. L'Alliance Francophone 39 pts. 10,446
• 6. Void Crushers 30 pts. 10,437
• 7. Deleted group pts. 10,435
• 8. Gargleblasters 17 pts. 10,381
• 9. HMT heritage 12 pts. 10,164
• 10. xkcd 9 pts. 9,597

Top soloists

• 1. gloverd 100 pts. 10,727
• 2. zeroblue 98 pts. 10,690
• 3. retiredmichael 96 pts. 10,690
• 4. reefyrob 93 pts. 10,655
• 5. MurloW 91 pts. 10,653
• 6. johnmitch 89 pts. 10,624
• 7. santex 87 pts. 10,577
• 8. BitSpawn 85 pts. 10,537
• 9. Galaxie 83 pts. 10,513
• 10. Bletchley Park 80 pts. 10,476

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.