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1093: 75 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Summary

Created: May 26, 2015
Expires: June 02, 2015 at 23:00 UTC
Max points: 100

Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. HMT heritage 4 pts. 9,380
12. Italiani Al Lavoro 3 pts. 9,357
13. FoldIt@Netherlands 2 pts. 9,030
14. xkcd 1 pt. 9,004
15. BOINC@Poland 1 pt. 8,508
16. Deleted group pts. 7,871
17. freefolder 1 pt. 7,669
18. Eὕρηκα! Heureka! 1 pt. 7,658
19. Crunching Family 1 pt. 7,410
20. DSN @ Home 1 pt. 7,098

11. spvincent Lv 1 86 pts. 10,256
12. gmn Lv 1 85 pts. 10,252
13. Madde Lv 1 83 pts. 10,234
14. Bruno Kestemont Lv 1 82 pts. 10,233
15. justjustin Lv 1 81 pts. 10,229
16. Enzyme Lv 1 79 pts. 10,221
17. Museka Lv 1 78 pts. 10,220
18. spmm Lv 1 77 pts. 10,203
19. Blipperman Lv 1 76 pts. 10,184
20. bertro Lv 1 74 pts. 10,158

Comments

bkoep Staff Lv 1

May 26, 2015

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.