Placeholder image of a protein
Icon representing a puzzle

1093: 75 Residue Monomer Design: Best Fragments

Closed since about 11 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design Design

Summary


Created
May 26, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for HMT heritage 11. HMT heritage 4 pts. 9,380
  2. Avatar for Italiani Al Lavoro 12. Italiani Al Lavoro 3 pts. 9,357
  3. Avatar for FoldIt@Netherlands 13. FoldIt@Netherlands 2 pts. 9,030
  4. Avatar for xkcd 14. xkcd 1 pt. 9,004
  5. Avatar for BOINC@Poland 15. BOINC@Poland 1 pt. 8,508
  6. Avatar for Deleted group 16. Deleted group pts. 7,871
  7. Avatar for freefolder 17. freefolder 1 pt. 7,669
  8. Avatar for Eὕρηκα! Heureka! 18. Eὕρηκα! Heureka! 1 pt. 7,658
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 7,410
  10. Avatar for DSN @ Home 20. DSN @ Home 1 pt. 7,098

  1. Avatar for The Trooper 301. The Trooper Lv 1 1 pt. 0
  2. Avatar for kalikas 302. kalikas Lv 1 1 pt. 0
  3. Avatar for franse 303. franse Lv 1 1 pt. 0
  4. Avatar for CesarCoello 304. CesarCoello Lv 1 1 pt. 0
  5. Avatar for Radamanto02 305. Radamanto02 Lv 1 1 pt. 0
  6. Avatar for napoleon13 306. napoleon13 Lv 1 1 pt. 0
  7. Avatar for wudoo 307. wudoo Lv 1 1 pt. 0
  8. Avatar for vatsal_ag 308. vatsal_ag Lv 1 1 pt. 0
  9. Avatar for avben 310. avben Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.