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1096: 70 Residue Monomer Design: Best Fragments

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
June 02, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 1,968
  2. Avatar for Window Group 22. Window Group 1 pt. 0
  3. Avatar for ROMANIA Team 23. ROMANIA Team 1 pt. 0
  4. Avatar for Minions of TWIS 24. Minions of TWIS 1 pt. 0
  5. Avatar for SETI.Germany 25. SETI.Germany 1 pt. 0

  1. Avatar for FreeFolder 151. FreeFolder Lv 1 1 pt. 7,570
  2. Avatar for stolly96 152. stolly96 Lv 1 1 pt. 7,553
  3. Avatar for v4mp1r3 153. v4mp1r3 Lv 1 1 pt. 7,552
  4. Avatar for NyteShade 154. NyteShade Lv 1 1 pt. 7,498
  5. Avatar for FalterSCAPICE 155. FalterSCAPICE Lv 1 1 pt. 7,433
  6. Avatar for Tac1 156. Tac1 Lv 1 1 pt. 7,406
  7. Avatar for BanditoCub 157. BanditoCub Lv 1 1 pt. 7,378
  8. Avatar for Siemy 158. Siemy Lv 1 1 pt. 7,378
  9. Avatar for Wimeved85 159. Wimeved85 Lv 1 1 pt. 7,376
  10. Avatar for ZeshSS 160. ZeshSS Lv 1 1 pt. 7,376

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.