Foldit

1102: Integrated Abeta Design

Closed since almost 11 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design Design

Summary

Created: June 17, 2015
Expires: June 24, 2015 at 23:00 UTC
Max points: 100

Description

This large protein (291 residues!) is based on a prenyltransferase protein from Streptomyces; however, we've inserted the sequence of Aβ into residues 267-291. We're asking Foldit players to redesign this protein so that it folds up normally with the integrated Aβ! Such a protein could serve as a starting point for the design of an Aβ binder.

Because this protein is so large, the backbone has been frozen; players may design all residues except 267-291 (Aβ sequence). Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!