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1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Summary

Created: June 25, 2015
Expires: July 02, 2015 at 23:00 UTC
Max points: 100

Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. Russian team 7 pts. 9,233
12. FoldIt@Netherlands 5 pts. 8,651
13. xkcd 4 pts. 8,612
14. Natural Abilities 3 pts. 8,481
15. BOINC@Poland 2 pts. 8,241
16. Deleted group pts. 7,921
17. Eὕρηκα! Heureka! 1 pt. 7,564
18. Dnice.dk 1 pt. 7,287
19. CureCoin 1 pt. 7,146
20. DSN @ Home 1 pt. 7,023

11. Bruno Kestemont Lv 1 81 pts. 10,362
12. Timo van der Laan Lv 1 80 pts. 10,362
13. nicobul Lv 1 78 pts. 10,353
14. LociOiling Lv 1 76 pts. 10,309
15. TomTaylor Lv 1 75 pts. 10,308
16. Galaxie Lv 1 73 pts. 10,306
17. Museka Lv 1 71 pts. 10,305
18. O Seki To Lv 1 70 pts. 10,290
19. Vredeman Lv 1 68 pts. 10,249
20. stomjoh Lv 1 67 pts. 10,235

Comments

bkoep Staff Lv 1

June 25, 2015

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.