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1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Intermediate Overall Design

Summary


Created
June 25, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Beta Folders 100 pts. 10,598
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 81 pts. 10,558
  3. Avatar for Contenders 3. Contenders 65 pts. 10,502
  4. Avatar for Go Science 4. Go Science 52 pts. 10,446
  5. Avatar for Gargleblasters 5. Gargleblasters 41 pts. 10,364
  6. Avatar for Void Crushers 6. Void Crushers 32 pts. 10,362
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 24 pts. 10,353
  8. Avatar for HMT heritage 8. HMT heritage 18 pts. 10,291
  9. Avatar for Deleted group 9. Deleted group pts. 10,287
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 10 pts. 9,311

  1. Avatar for Merf 181. Merf Lv 1 1 pt. 3,205
  2. Avatar for Inkedhands 182. Inkedhands Lv 1 1 pt. 3,082
  3. Avatar for 01010011111 183. 01010011111 Lv 1 1 pt. 2,865
  4. Avatar for pfeiffelfloyd 184. pfeiffelfloyd Lv 1 1 pt. 1,110
  5. Avatar for YGK 185. YGK Lv 1 1 pt. 1,069
  6. Avatar for felix1998 186. felix1998 Lv 1 1 pt. 0
  7. Avatar for Alza 18 187. Alza 18 Lv 1 1 pt. 0
  8. Avatar for toocajun 188. toocajun Lv 1 1 pt. 0
  9. Avatar for Ling Ying 189. Ling Ying Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.