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1106: 80 Residue Monomer Design: Best Fragments

Closed since over 10 years ago

Intermediate Overall Design

Summary


Created
June 25, 2015
Expires
Max points
100
Description

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  1. Avatar for cor2020 192. cor2020 Lv 1 1 pt. 0
  2. Avatar for pizza12 193. pizza12 Lv 1 1 pt. 0
  3. Avatar for leehaggis 194. leehaggis Lv 1 1 pt. 0
  4. Avatar for FarzadBekran 195. FarzadBekran Lv 1 1 pt. 0
  5. Avatar for Aldrovanda 196. Aldrovanda Lv 1 1 pt. 0
  6. Avatar for napen123 197. napen123 Lv 1 1 pt. 0
  7. Avatar for vpswede 198. vpswede Lv 1 1 pt. 0
  8. Avatar for deep999 199. deep999 Lv 1 1 pt. 0
  9. Avatar for Jacob Wison 200. Jacob Wison Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.