Placeholder image of a protein
Icon representing a puzzle

1125: 60 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary


Created
August 12, 2015
Expires
Max points
100
Description

This is a small 60 residue design puzzle. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Anthropic Dreams 100 pts. 10,165
  2. Avatar for Gargleblasters 2. Gargleblasters 78 pts. 10,038
  3. Avatar for Go Science 3. Go Science 60 pts. 10,029
  4. Avatar for Beta Folders 4. Beta Folders 45 pts. 10,024
  5. Avatar for Contenders 5. Contenders 33 pts. 10,011
  6. Avatar for Void Crushers 6. Void Crushers 24 pts. 10,004
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 17 pts. 9,963
  8. Avatar for Deleted group 8. Deleted group pts. 9,956
  9. Avatar for HMT heritage 9. HMT heritage 8 pts. 9,893
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 6 pts. 9,611

  1. Avatar for Mat0Man 201. Mat0Man Lv 1 1 pt. 0
  2. Avatar for mgold99 202. mgold99 Lv 1 1 pt. 0
  3. Avatar for hada 203. hada Lv 1 1 pt. 0
  4. Avatar for molleke 204. molleke Lv 1 1 pt. 0
  5. Avatar for Kren 205. Kren Lv 1 1 pt. 0
  6. Avatar for Antibrad 206. Antibrad Lv 1 1 pt. 0
  7. Avatar for Schleicher 207. Schleicher Lv 1 1 pt. 0
  8. Avatar for Timoleon 208. Timoleon Lv 1 1 pt. 0
  9. Avatar for sheerbliss 209. sheerbliss Lv 1 1 pt. 0
  10. Avatar for multaq 210. multaq Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.