Placeholder image of a protein
Icon representing a puzzle

1169: 75 Residue Monomer Design

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
December 11, 2015
Expires
Max points
100
Description

This is a basic 75 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,502
  2. Avatar for Gargleblasters 2. Gargleblasters 77 pts. 10,495
  3. Avatar for Go Science 3. Go Science 58 pts. 10,491
  4. Avatar for Beta Folders 4. Beta Folders 43 pts. 10,488
  5. Avatar for Contenders 5. Contenders 31 pts. 10,460
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 22 pts. 10,396
  7. Avatar for Void Crushers 7. Void Crushers 15 pts. 10,378
  8. Avatar for Deleted group 8. Deleted group pts. 10,196
  9. Avatar for HMT heritage 9. HMT heritage 7 pts. 10,150
  10. Avatar for xkcd 10. xkcd 5 pts. 10,040
  1. Avatar for rarmstrong19 211. rarmstrong19 Lv 1 1 pt. 0
  2. Avatar for MFVGML 212. MFVGML Lv 1 1 pt. 0
  3. Avatar for stephenrl 213. stephenrl Lv 1 1 pt. 0
  4. Avatar for z13z 214. z13z Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.