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1169: 75 Residue Monomer Design

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
December 11, 2015
Expires
Max points
100
Description

This is a basic 75 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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  1. Avatar for Inkedhands 191. Inkedhands Lv 1 1 pt. 0
  2. Avatar for petetrig 192. petetrig Lv 1 1 pt. 0
  3. Avatar for dettingen 193. dettingen Lv 1 1 pt. 0
  4. Avatar for ImASushiRoll 194. ImASushiRoll Lv 1 1 pt. 0
  5. Avatar for tarimo 195. tarimo Lv 1 1 pt. 0
  6. Avatar for bendbob 196. bendbob Lv 1 1 pt. 0
  7. Avatar for zkm 197. zkm Lv 1 1 pt. 0
  8. Avatar for kncrissinger0 198. kncrissinger0 Lv 1 1 pt. 0
  9. Avatar for thekraken14 199. thekraken14 Lv 1 1 pt. 0
  10. Avatar for agnairt 200. agnairt Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.