Placeholder image of a protein
Icon representing a puzzle

1202: 75 Residue Monomer Design

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
March 04, 2016
Expires
Max points
100
Description

This is a basic 75 residue design puzzle with slightly up-weighted ideality scoring. Players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 10,405
  2. Avatar for Contenders 2. Contenders 77 pts. 10,394
  3. Avatar for Gargleblasters 3. Gargleblasters 58 pts. 10,387
  4. Avatar for Beta Folders 4. Beta Folders 43 pts. 10,386
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 31 pts. 10,381
  6. Avatar for Go Science 6. Go Science 22 pts. 10,362
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 15 pts. 10,260
  8. Avatar for HMT heritage 8. HMT heritage 11 pts. 10,257
  9. Avatar for Deleted group 9. Deleted group pts. 9,968
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 5 pts. 9,856
  1. Avatar for Timo van der Laan
    1. Timo van der Laan Lv 1
    100 pts. 10,403
  2. Avatar for retiredmichael 2. retiredmichael Lv 1 98 pts. 10,385
  3. Avatar for Galaxie 3. Galaxie Lv 1 96 pts. 10,376
  4. Avatar for MurloW 4. MurloW Lv 1 94 pts. 10,367
  5. Avatar for Scopper 5. Scopper Lv 1 92 pts. 10,362
  6. Avatar for Mark- 6. Mark- Lv 1 90 pts. 10,360
  7. Avatar for Skippysk8s 7. Skippysk8s Lv 1 88 pts. 10,358
  8. Avatar for frood66 8. frood66 Lv 1 86 pts. 10,353
  9. Avatar for hpaege 9. hpaege Lv 1 84 pts. 10,350
  10. Avatar for Bruno Kestemont 10. Bruno Kestemont Lv 1 82 pts. 10,348

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Skippysk8s Lv 1

Often during set up I may ignore some filters. It would be handy to post total filter points once I am ready to move from hand folding to recipes, as many ask for total filter score. I have been guessing…
Thanks