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1202: 75 Residue Monomer Design

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
March 04, 2016
Expires
Max points
100
Description

This is a basic 75 residue design puzzle with slightly up-weighted ideality scoring. Players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Skippysk8s Lv 1

Often during set up I may ignore some filters. It would be handy to post total filter points once I am ready to move from hand folding to recipes, as many ask for total filter score. I have been guessing…
Thanks