1205: 75 Residue Monomer Design: Helical Bundles

Closed since almost 10 years ago

Summary

• Created: March 10, 2016
• Expires: March 17, 2016 at 23:00 UTC
• Max points: 100

Description

This is a basic 75 residue design puzzle with no secondary structure filter—helical bundles welcome! Ideality scoring is also up-weighted, so players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Contenders 100 pts. 10,091
• 2. Beta Folders 80 pts. 10,077
• 3. Anthropic Dreams 63 pts. 10,063
• 4. Go Science 49 pts. 10,062
• 5. Void Crushers 37 pts. 9,965
• 6. Gargleblasters 28 pts. 9,950
• 7. L'Alliance Francophone 21 pts. 9,894
• 8. HMT heritage 15 pts. 9,835
• 9. Deleted group pts. 9,781
• 10. Italiani Al Lavoro 8 pts. 9,490

Top soloists

• 1. Mark- 100 pts. 10,076
• 2. retiredmichael 98 pts. 10,066
• 3. Bruno Kestemont 96 pts. 10,062
• 4. Galaxie 94 pts. 10,062
• 5. MurloW 92 pts. 10,060
• 6. johnmitch 90 pts. 10,058
• 7. Deleted player pts. 10,041
• 8. bertro 86 pts. 10,021
• 9. hpaege 84 pts. 10,007
• 10. jamiexq 82 pts. 9,981

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.