Placeholder image of a protein
Icon representing a puzzle

1205: 75 Residue Monomer Design: Helical Bundles

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
March 10, 2016
Expires
Max points
100
Description

This is a basic 75 residue design puzzle with no secondary structure filter—helical bundles welcome! Ideality scoring is also up-weighted, so players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for xkcd 11. xkcd 5 pts. 9,489
  2. Avatar for SETI.Germany 12. SETI.Germany 4 pts. 9,316
  3. Avatar for Russian team 13. Russian team 2 pts. 9,033
  4. Avatar for BOINC@Poland 14. BOINC@Poland 2 pts. 9,029
  5. Avatar for Natural Abilities 15. Natural Abilities 1 pt. 8,469
  6. Avatar for Team South Africa 16. Team South Africa 1 pt. 8,322
  7. Avatar for Rechenkraft.net 17. Rechenkraft.net 1 pt. 7,817
  8. Avatar for freefolder 18. freefolder 1 pt. 7,573
  9. Avatar for Deleted group 19. Deleted group pts. 7,326
  10. Avatar for Bad Monkey 20. Bad Monkey 1 pt. 7,148
  1. Avatar for gitwut
    1. gitwut Lv 1
    100 pts. 10,091
  2. Avatar for TomTaylor 2. TomTaylor Lv 1 87 pts. 10,086
  3. Avatar for Bletchley Park 3. Bletchley Park Lv 1 75 pts. 10,085
  4. Avatar for Mark- 4. Mark- Lv 1 64 pts. 10,084
  5. Avatar for mimi 5. mimi Lv 1 55 pts. 10,079
  6. Avatar for reefyrob 6. reefyrob Lv 1 47 pts. 10,077
  7. Avatar for LociOiling 7. LociOiling Lv 1 40 pts. 10,075
  8. Avatar for smilingone 8. smilingone Lv 1 33 pts. 10,074
  9. Avatar for bertro 9. bertro Lv 1 28 pts. 10,065
  10. Avatar for Deleted player 10. Deleted player pts. 10,063

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.