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1205: 75 Residue Monomer Design: Helical Bundles

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
March 10, 2016
Expires
Max points
100
Description

This is a basic 75 residue design puzzle with no secondary structure filter—helical bundles welcome! Ideality scoring is also up-weighted, so players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 6,862
  2. Avatar for Chem251-601 Spring 2016 22. Chem251-601 Spring 2016 1 pt. 2,141
  3. Avatar for Window Group 23. Window Group 1 pt. 0
  1. Avatar for navn 121. navn Lv 1 3 pts. 8,636
  2. Avatar for NameChangeNeeded01 122. NameChangeNeeded01 Lv 1 3 pts. 8,620
  3. Avatar for hansvandenhof 123. hansvandenhof Lv 1 3 pts. 8,615
  4. Avatar for PrettyPony2001 124. PrettyPony2001 Lv 1 2 pts. 8,614
  5. Avatar for Superphosphate 125. Superphosphate Lv 1 2 pts. 8,599
  6. Avatar for ecali 126. ecali Lv 1 2 pts. 8,599
  7. Avatar for SALiquidSilver 127. SALiquidSilver Lv 1 2 pts. 8,554
  8. Avatar for momadoc 128. momadoc Lv 1 2 pts. 8,538
  9. Avatar for mitarcher 129. mitarcher Lv 1 2 pts. 8,500
  10. Avatar for pfirth 130. pfirth Lv 1 2 pts. 8,495

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.