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1205: 75 Residue Monomer Design: Helical Bundles

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
March 10, 2016
Expires
Max points
100
Description

This is a basic 75 residue design puzzle with no secondary structure filter—helical bundles welcome! Ideality scoring is also up-weighted, so players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 6,862
  2. Avatar for Chem251-601 Spring 2016 22. Chem251-601 Spring 2016 1 pt. 2,141
  3. Avatar for Window Group 23. Window Group 1 pt. 0
  1. Avatar for HMK 151. HMK Lv 1 1 pt. 7,817
  2. Avatar for johngran 152. johngran Lv 1 1 pt. 7,754
  3. Avatar for Wheeler22 153. Wheeler22 Lv 1 1 pt. 7,623
  4. Avatar for Altercomp 154. Altercomp Lv 1 1 pt. 7,573
  5. Avatar for M Ghiorso iii 155. M Ghiorso iii Lv 1 1 pt. 7,570
  6. Avatar for jeffjamebart 156. jeffjamebart Lv 1 1 pt. 7,528
  7. Avatar for Punktchen 157. Punktchen Lv 1 1 pt. 7,407
  8. Avatar for Gracier 158. Gracier Lv 1 1 pt. 7,402
  9. Avatar for tscarberry1 159. tscarberry1 Lv 1 1 pt. 7,326
  10. Avatar for Mr.Clover 160. Mr.Clover Lv 1 1 pt. 7,295

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.