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1205: 75 Residue Monomer Design: Helical Bundles

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
March 10, 2016
Expires
Max points
100
Description

This is a basic 75 residue design puzzle with no secondary structure filter—helical bundles welcome! Ideality scoring is also up-weighted, so players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  1. Avatar for jetcheung 191. jetcheung Lv 1 1 pt. 2,395
  2. Avatar for amensch 192. amensch Lv 1 1 pt. 2,393
  3. Avatar for SWR_DMaster 193. SWR_DMaster Lv 1 1 pt. 2,384
  4. Avatar for BluePop 194. BluePop Lv 1 1 pt. 2,304
  5. Avatar for Ellis Shih 195. Ellis Shih Lv 1 1 pt. 2,167
  6. Avatar for ling1134 196. ling1134 Lv 1 1 pt. 2,162
  7. Avatar for tacar 197. tacar Lv 1 1 pt. 2,161
  8. Avatar for e666666 198. e666666 Lv 1 1 pt. 2,160
  9. Avatar for kkkkkk 199. kkkkkk Lv 1 1 pt. 2,160
  10. Avatar for Jiri_Holzel_CZ 200. Jiri_Holzel_CZ Lv 1 1 pt. 2,160

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.