Placeholder image of a protein
Icon representing a puzzle

1205: 75 Residue Monomer Design: Helical Bundles

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
March 10, 2016
Expires
Max points
100
Description

This is a basic 75 residue design puzzle with no secondary structure filter—helical bundles welcome! Ideality scoring is also up-weighted, so players should take care that all cutpoints are closed with good geometry! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 10,091
  2. Avatar for Beta Folders 2. Beta Folders 80 pts. 10,077
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 63 pts. 10,063
  4. Avatar for Go Science 4. Go Science 49 pts. 10,062
  5. Avatar for Void Crushers 5. Void Crushers 37 pts. 9,965
  6. Avatar for Gargleblasters 6. Gargleblasters 28 pts. 9,950
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 21 pts. 9,894
  8. Avatar for HMT heritage 8. HMT heritage 15 pts. 9,835
  9. Avatar for Deleted group 9. Deleted group pts. 9,781
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 8 pts. 9,490
  1. Avatar for SouperGenious 101. SouperGenious Lv 1 6 pts. 8,828
  2. Avatar for GoodGuyGreg 102. GoodGuyGreg Lv 1 6 pts. 8,802
  3. Avatar for Franco Padelletti 103. Franco Padelletti Lv 1 5 pts. 8,795
  4. Avatar for Tac1 104. Tac1 Lv 1 5 pts. 8,787
  5. Avatar for parsnip 105. parsnip Lv 1 5 pts. 8,774
  6. Avatar for arginia 106. arginia Lv 1 5 pts. 8,728
  7. Avatar for Merf 107. Merf Lv 1 5 pts. 8,716
  8. Avatar for bzipitidoo 108. bzipitidoo Lv 1 4 pts. 8,713
  9. Avatar for Festering Wounds 109. Festering Wounds Lv 1 4 pts. 8,696
  10. Avatar for Truncheon Luncheon 110. Truncheon Luncheon Lv 1 4 pts. 8,694

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.