Placeholder image of a protein
Icon representing a puzzle

1208: 75 Residue Monomer Design: Rama Map

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
March 16, 2016
Expires
Max points
100
Description

This puzzle premieres a new tool, the Rama Map, which is meant to give players more control of the protein backbone. The Rama map can be accessed from the Actions tab (Original Interface) or the Main menu (Selection Interface). See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for BOINC@Poland 11. BOINC@Poland 8 pts. 9,618
  2. Avatar for xkcd 12. xkcd 6 pts. 9,219
  3. Avatar for Russian team 13. Russian team 4 pts. 8,737
  4. Avatar for Rechenkraft.net 14. Rechenkraft.net 3 pts. 8,486
  5. Avatar for Newbs to Experts 15. Newbs to Experts 2 pts. 8,406
  6. Avatar for Team South Africa 16. Team South Africa 2 pts. 8,402
  7. Avatar for It's over 9000! 17. It's over 9000! 1 pt. 7,782
  8. Avatar for Chem251-601 Spring 2016 18. Chem251-601 Spring 2016 1 pt. 7,095
  9. Avatar for DSN @ Home 19. DSN @ Home 1 pt. 6,439
  10. Avatar for SETI.Germany 20. SETI.Germany 1 pt. 5,297
  1. Avatar for grogar7 51. grogar7 Lv 1 28 pts. 10,041
  2. Avatar for joremen 52. joremen Lv 1 27 pts. 10,021
  3. Avatar for andrewxc 53. andrewxc Lv 1 27 pts. 10,021
  4. Avatar for Mike Lewis 54. Mike Lewis Lv 1 26 pts. 10,017
  5. Avatar for phi16 55. phi16 Lv 1 25 pts. 10,003
  6. Avatar for deLaCeiba 56. deLaCeiba Lv 1 24 pts. 9,991
  7. Avatar for Bushman 57. Bushman Lv 1 24 pts. 9,964
  8. Avatar for jobo0502 58. jobo0502 Lv 1 23 pts. 9,958
  9. Avatar for alcor29 59. alcor29 Lv 1 22 pts. 9,957
  10. Avatar for sheerbliss 60. sheerbliss Lv 1 22 pts. 9,936

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.