1214: 65 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Summary

• Created: March 31, 2016
• Expires: April 07, 2016 at 23:00 UTC
• Max points: 100

Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 65 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!



Note: If you have experienced slow performance in recent design puzzles, please try the companion devprev puzzle with disabled Rama Map.

Top groups

• 1. Contenders 100 pts. 10,218
• 2. Void Crushers 81 pts. 10,124
• 3. Anthropic Dreams 64 pts. 10,118
• 4. Go Science 50 pts. 10,111
• 5. Beta Folders 39 pts. 10,096
• 6. Gargleblasters 30 pts. 10,055
• 7. L'Alliance Francophone 23 pts. 10,016
• 8. HMT heritage 17 pts. 9,947
• 9. Deleted group pts. 9,759
• 10. Italiani Al Lavoro 9 pts. 9,692

Top soloists

• 1. Mark- 100 pts. 10,187
• 2. spvincent 98 pts. 10,145
• 3. Timo van der Laan 96 pts. 10,124
• 4. gitwut 93 pts. 10,116
• 5. Galaxie 91 pts. 10,115
• 6. Bruno Kestemont 88 pts. 10,111
• 7. TomTaylor 86 pts. 10,099
• 8. Scopper 84 pts. 10,095
• 9. KarenCH 82 pts. 10,094
• 10. Deleted player pts. 10,091

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 65 residue limit. Players may insert up to 10 extra residues.

[gitwut]

The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress.

How would temporarily adding residues be beneficial? Just curious.

[Skippysk8s]

make what was a sheet into a helix, switch another helix to sheet. can add to one, subtract from other without redoing whole fold. good for those of us with poor layout skills :D

[Timo van der Laan]

Compared performance on several recipes.
The performance penalty varies between 10 and 20 percent.
I can not find real difference between the different tools wiggle, shake, mutate and rebuild, it looks like all tools are somehow effected.