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1269: 90 Residue Monomer Design: More Sheets!

Closed since over 9 years ago

Intermediate Overall Design

Summary

Created
August 06, 2016
Expires
Max points
100
Description

This puzzle challenges players to design proteins with more sheets! Designs should include at least 50% residues in sheet conformation. The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."