Placeholder image of a protein
Icon representing a puzzle

1269: 90 Residue Monomer Design: More Sheets!

Closed since over 9 years ago

Intermediate Intermediate Overall Overall Design Design

Summary

Created
August 06, 2016
Expires
Max points
100
Description

This puzzle challenges players to design proteins with more sheets! Designs should include at least 50% residues in sheet conformation. The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for SETI.Germany 11. SETI.Germany 1 pt. 6,581
  2. Avatar for freefolder 12. freefolder 1 pt. 3,931
  3. Avatar for DSN @ Home 13. DSN @ Home 1 pt. 0
  1. Avatar for bx7gn 91. bx7gn Lv 1 1 pt. 4,115
  2. Avatar for dbuske 92. dbuske Lv 1 1 pt. 4,093
  3. Avatar for DotMatrix 93. DotMatrix Lv 1 1 pt. 3,962
  4. Avatar for Altercomp 94. Altercomp Lv 1 1 pt. 3,931
  5. Avatar for Simek 95. Simek Lv 1 1 pt. 3,795
  6. Avatar for froggs554 96. froggs554 Lv 1 1 pt. 3,787
  7. Avatar for taminnugget 97. taminnugget Lv 1 1 pt. 3,467
  8. Avatar for Tac1 98. Tac1 Lv 1 1 pt. 3,116
  9. Avatar for eromana 99. eromana Lv 1 1 pt. 2,832
  10. Avatar for pemmer77 100. pemmer77 Lv 1 1 pt. 2,692

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."