1275: 65 Residue Monomer Design: Helical Bundles

Closed since over 9 years ago

Summary

• Created: August 22, 2016
• Expires: August 29, 2016 at 23:00 UTC
• Max points: 100

Description

This is a basic 65 residue design puzzle with no secondary structure filter—helical bundles welcome! The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Beta Folders 100 pts. 9,839
• 2. Anthropic Dreams 71 pts. 9,747
• 3. Contenders 49 pts. 9,745
• 4. Go Science 33 pts. 9,737
• 5. Gargleblasters 22 pts. 9,682
• 6. HMT heritage 14 pts. 9,634
• 7. Void Crushers 8 pts. 9,579
• 8. L'Alliance Francophone 5 pts. 9,558
• 9. Herobrine's Army 3 pts. 9,213
• 10. Deleted group pts. 8,959

Top soloists

• 41. angeltrouble 25 pts. 9,448
• 42. pvc78 24 pts. 9,443
• 43. caglar 23 pts. 9,439
• 44. jobo0502 22 pts. 9,383
• 45. uihcv 21 pts. 9,368
• 46. smilingone 20 pts. 9,328
• 47. smholst 19 pts. 9,322
• 48. ViJay7019 19 pts. 9,305
• 49. Anfinsen_slept_here 18 pts. 9,296
• 50. Vinara 17 pts. 9,268

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 65 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."