Placeholder image of a protein
Icon representing a puzzle

1275: 65 Residue Monomer Design: Helical Bundles

Closed since over 9 years ago

Intermediate Overall Design

Summary

Created
August 22, 2016
Expires
Max points
100
Description

This is a basic 65 residue design puzzle with no secondary structure filter—helical bundles welcome! The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 9,839
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 71 pts. 9,747
  3. Avatar for Contenders 3. Contenders 49 pts. 9,745
  4. Avatar for Go Science 4. Go Science 33 pts. 9,737
  5. Avatar for Gargleblasters 5. Gargleblasters 22 pts. 9,682
  6. Avatar for HMT heritage 6. HMT heritage 14 pts. 9,634
  7. Avatar for Void Crushers 7. Void Crushers 8 pts. 9,579
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 5 pts. 9,558
  9. Avatar for Herobrine's Army 9. Herobrine's Army 3 pts. 9,213
  10. Avatar for Deleted group 10. Deleted group pts. 8,959
  1. Avatar for georg137 61. georg137 Lv 1 10 pts. 9,110
  2. Avatar for weitzen 62. weitzen Lv 1 10 pts. 9,070
  3. Avatar for joremen 63. joremen Lv 1 9 pts. 9,064
  4. Avatar for dssb 64. dssb Lv 1 9 pts. 8,982
  5. Avatar for dizzywings 65. dizzywings Lv 1 9 pts. 8,973
  6. Avatar for JayD7217 66. JayD7217 Lv 1 8 pts. 8,969
  7. Avatar for drumpeter18yrs9yrs 67. drumpeter18yrs9yrs Lv 1 8 pts. 8,959
  8. Avatar for YeshuaLives 68. YeshuaLives Lv 1 7 pts. 8,954
  9. Avatar for alcor29 69. alcor29 Lv 1 7 pts. 8,949
  10. Avatar for tallguy-13088 70. tallguy-13088 Lv 1 7 pts. 8,943

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 65 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."