1282: 70 Residue Monomer Design: Helical Bundles

Closed since over 9 years ago

Summary

• Created: September 08, 2016
• Expires: September 15, 2016 at 23:00 UTC
• Max points: 100

Description

This is a basic 70 residue design puzzle with no secondary structure filter—helical bundles welcome! The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Contenders 100 pts. 9,986
• 2. Beta Folders 70 pts. 9,950
• 3. Anthropic Dreams 47 pts. 9,904
• 4. Gargleblasters 30 pts. 9,900
• 5. Go Science 19 pts. 9,894
• 6. L'Alliance Francophone 11 pts. 9,853
• 7. Void Crushers 7 pts. 9,788
• 8. Deleted group pts. 9,682
• 9. HMT heritage 2 pts. 9,666
• 10. Italiani Al Lavoro 1 pt. 9,163

Top soloists

• 151. WBarme1234 1 pt. 0

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 70 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."