1313: 85 Residue Monomer Design: Blueprint

Closed since over 9 years ago

Summary

• Created: December 03, 2016
• Expires: December 10, 2016 at 23:00 UTC
• Max points: 100

Description

Note: The starting structure has only 70 residues, but players are encouraged to add residues up to a total of 85! The disparity in residue number allows sharing of solutions from Puzzle 1302, which was posted with a faulty Residue Count filter and awarded no points. We apologize for any inconvenience!



This puzzle features the new Blueprint panel, which can be accessed from the Actions menu (or the Main menu in Selection Interface). See the blog for more information. Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Anthropic Dreams 100 pts. 10,693
• 2. Contenders 76 pts. 10,692
• 3. Beta Folders 56 pts. 10,670
• 4. Gargleblasters 41 pts. 10,621
• 5. Go Science 29 pts. 10,582
• 6. Void Crushers 20 pts. 10,515
• 7. L'Alliance Francophone 14 pts. 10,450
• 8. Deleted group pts. 9,652
• 9. Italiani Al Lavoro 6 pts. 9,132
• 10. Russian team 4 pts. 8,896

Top soloists

• 1. bertro 100 pts. 10,670
• 2. tokens 97 pts. 10,664
• 3. LociOiling 95 pts. 10,661
• 4. markm457 92 pts. 10,628
• 5. ZeroLeak7 89 pts. 10,582
• 6. Bletchley Park 86 pts. 10,568
• 7. retiredmichael 83 pts. 10,567
• 8. actiasluna 81 pts. 10,567
• 9. Susume 78 pts. 10,561
• 10. dcrwheeler 76 pts. 10,539

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

[Bruno Kestemont]

I can go to 95 residues

[Bletchley Park]

Bruno, yes you can but the penalty for adding residues over 85 should quickly deter you from doing so. I noticed a 10000 point penalty for 95 residues.

[Bruno Kestemont]

indeed, I didn't notice while I was in huge negative points

[alwen]

This is the slowest puzzle I've worked on recently. It takes my PC as long as 10 minutes to grind through 3 iterations of wiggle. The fact that I'm on the scoreboard at all is only due to my stubbornness.