Placeholder image of a protein
Icon representing a puzzle

1321: 90 Residue Monomer Design: Blueprint

Closed since about 9 years ago

Intermediate Overall Design

Summary


Created
December 23, 2016
Expires
Max points
100
Description

This puzzle features the new Blueprint panel, which can be accessed from the Actions menu (or the Main menu in Selection Interface). See the blog for more information. Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Anthropic Dreams 100 pts. 10,830
  2. Avatar for Beta Folders 2. Beta Folders 68 pts. 10,816
  3. Avatar for Gargleblasters 3. Gargleblasters 44 pts. 10,805
  4. Avatar for Go Science 4. Go Science 27 pts. 10,781
  5. Avatar for Contenders 5. Contenders 16 pts. 10,704
  6. Avatar for Void Crushers 6. Void Crushers 9 pts. 10,639
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 5 pts. 10,555
  8. Avatar for Deleted group 8. Deleted group pts. 9,991
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 1 pt. 9,634
  10. Avatar for xkcd 10. xkcd 1 pt. 8,413

  1. Avatar for LociOiling
    1. LociOiling Lv 1
    100 pts. 10,816
  2. Avatar for actiasluna 2. actiasluna Lv 1 97 pts. 10,801
  3. Avatar for ZeroLeak7 3. ZeroLeak7 Lv 1 93 pts. 10,781
  4. Avatar for tokens 4. tokens Lv 1 90 pts. 10,776
  5. Avatar for fiendish_ghoul 5. fiendish_ghoul Lv 1 86 pts. 10,714
  6. Avatar for Galaxie 6. Galaxie Lv 1 83 pts. 10,687
  7. Avatar for Scopper 7. Scopper Lv 1 80 pts. 10,679
  8. Avatar for Bruno Kestemont 8. Bruno Kestemont Lv 1 77 pts. 10,661
  9. Avatar for pauldunn 9. pauldunn Lv 1 74 pts. 10,651
  10. Avatar for markm457 10. markm457 Lv 1 71 pts. 10,650

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."