Placeholder image of a protein
Icon representing a puzzle

1334: 90 Residue Monomer Design: Blueprint

Closed since about 9 years ago

Intermediate Overall Design

Summary

Created
January 26, 2017
Expires
Max points
100
Description

This puzzle omits the Ideal Loop Filter; we're leaving it up to players to find their own high-scoring loops! The Blueprint panel is still available, which can be accessed from the Actions menu (or the Main menu in Selection Interface). Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,835
  2. Avatar for Beta Folders 2. Beta Folders 70 pts. 10,823
  3. Avatar for Go Science 3. Go Science 47 pts. 10,737
  4. Avatar for Contenders 4. Contenders 30 pts. 10,720
  5. Avatar for Gargleblasters 5. Gargleblasters 19 pts. 10,636
  6. Avatar for Void Crushers 6. Void Crushers 11 pts. 10,590
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 7 pts. 10,558
  8. Avatar for Italiani Al Lavoro 8. Italiani Al Lavoro 4 pts. 10,116
  9. Avatar for Team South Africa 9. Team South Africa 2 pts. 8,237
  10. Avatar for Deleted group 10. Deleted group pts. 7,620
  1. Avatar for markm457
    1. markm457 Lv 1
    100 pts. 10,831
  2. Avatar for retiredmichael 2. retiredmichael Lv 1 98 pts. 10,789
  3. Avatar for jermainiac 3. jermainiac Lv 1 95 pts. 10,786
  4. Avatar for MurloW 4. MurloW Lv 1 92 pts. 10,784
  5. Avatar for LociOiling 5. LociOiling Lv 1 89 pts. 10,759
  6. Avatar for reefyrob 6. reefyrob Lv 1 86 pts. 10,752
  7. Avatar for bertro 7. bertro Lv 1 84 pts. 10,751
  8. Avatar for tokens 8. tokens Lv 1 81 pts. 10,744
  9. Avatar for Vinara 9. Vinara Lv 1 79 pts. 10,740
  10. Avatar for ZeroLeak7 10. ZeroLeak7 Lv 1 76 pts. 10,737

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.