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1334: 90 Residue Monomer Design: Blueprint

Closed since about 9 years ago

Intermediate Overall Design

Summary

Created: January 26, 2017
Expires: February 02, 2017 at 23:00 UTC
Max points: 100

Description

This puzzle omits the Ideal Loop Filter; we're leaving it up to players to find their own high-scoring loops! The Blueprint panel is still available, which can be accessed from the Actions menu (or the Main menu in Selection Interface). Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. xkcd 1 pt. 7,579
12. SciOne2017 1 pt. 7,032
13. DSN @ Home 1 pt. 6,750
14. Natural Abilities 1 pt. 4,919
15. GUGITBIOTECH 1 pt. 1,699

1. Galaxie Lv 1
100 pts. 10,835
2. LociOiling Lv 1 83 pts. 10,823
3. smilingone Lv 1 69 pts. 10,821
4. reefyrob Lv 1 56 pts. 10,818
5. phi16 Lv 1 45 pts. 10,811
6. retiredmichael Lv 1 36 pts. 10,807
7. gmn Lv 1 29 pts. 10,802
8. lamoille Lv 1 23 pts. 10,781
9. jermainiac Lv 1 18 pts. 10,780
10. alcor29 Lv 1 14 pts. 10,756

Comments

bkoep Staff Lv 1

January 26, 2017

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.