Placeholder image of a protein
Icon representing a puzzle

1349: 75 Residue Monomer Design: Helix Restrictions

Closed since about 9 years ago

Intermediate Overall Design

Summary

Created
March 04, 2017
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 10,453
  2. Avatar for Beta Folders 2. Beta Folders 70 pts. 10,446
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 47 pts. 10,394
  4. Avatar for Contenders 4. Contenders 30 pts. 10,343
  5. Avatar for Go Science 5. Go Science 19 pts. 10,331
  6. Avatar for Void Crushers 6. Void Crushers 11 pts. 10,229
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 7 pts. 10,214
  8. Avatar for Deleted group 8. Deleted group pts. 10,064
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 2 pts. 9,397
  10. Avatar for Piratenpartei Deutschland 10. Piratenpartei Deutschland 1 pt. 8,817
  1. Avatar for JUMELLE54 71. JUMELLE54 Lv 1 5 pts. 8,622
  2. Avatar for rabamino12358 72. rabamino12358 Lv 1 4 pts. 8,601
  3. Avatar for froggs554 73. froggs554 Lv 1 4 pts. 8,582
  4. Avatar for navn 74. navn Lv 1 4 pts. 8,496
  5. Avatar for SouperGenious 75. SouperGenious Lv 1 4 pts. 8,484
  6. Avatar for SKSbell 76. SKSbell Lv 1 3 pts. 8,480
  7. Avatar for harvardman 77. harvardman Lv 1 3 pts. 8,371
  8. Avatar for gu14003 78. gu14003 Lv 1 3 pts. 8,321
  9. Avatar for Cerzax 79. Cerzax Lv 1 3 pts. 8,292
  10. Avatar for pfirth 80. pfirth Lv 1 3 pts. 8,277

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the 75 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."