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1352: 90 Residue Monomer Design: Helix Restrictions

Closed since about 9 years ago

Intermediate Overall Design

Summary


Created
March 12, 2017
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  4. Avatar for LEC Metabolites 14. LEC Metabolites 1 pt. 979
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  1. Avatar for 01010011111 121. 01010011111 Lv 1 1 pt. 3,169
  2. Avatar for 1210115146 122. 1210115146 Lv 1 1 pt. 2,659
  3. Avatar for w_zolnierowicz 123. w_zolnierowicz Lv 1 1 pt. 2,506
  4. Avatar for tweak64 124. tweak64 Lv 1 1 pt. 2,267
  5. Avatar for Alekhya.vytla 125. Alekhya.vytla Lv 1 1 pt. 2,169
  6. Avatar for Chris1_PCT 126. Chris1_PCT Lv 1 1 pt. 1,454
  7. Avatar for BIO257C-blozano 127. BIO257C-blozano Lv 1 1 pt. 1,313
  8. Avatar for NotJim99 128. NotJim99 Lv 1 1 pt. 1,154
  9. Avatar for hansvandenhof 129. hansvandenhof Lv 1 1 pt. 1,154
  10. Avatar for pratt93 130. pratt93 Lv 1 1 pt. 979

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."