1355: 100 Residue Monomer Design: Helix Restrictions

Closed since almost 9 years ago

Summary

• Created: March 18, 2017
• Expires: March 26, 2017 at 23:00 UTC
• Max points: 100

Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Anthropic Dreams 100 pts. 11,055
• 2. Beta Folders 81 pts. 11,017
• 3. Void Crushers 65 pts. 10,926
• 4. Go Science 52 pts. 10,899
• 5. Gargleblasters 41 pts. 10,865
• 6. Contenders 32 pts. 10,816
• 7. Deleted group pts. 10,596
• 8. L'Alliance Francophone 18 pts. 10,519
• 9. FoldIt@Netherlands 14 pts. 10,329
• 10. Italiani Al Lavoro 10 pts. 10,255

Top soloists

• 1. tokens 100 pts. 11,021
• 2. Galaxie 98 pts. 11,009
• 3. retiredmichael 95 pts. 10,980
• 4. dcrwheeler 92 pts. 10,970
• 5. markm457 90 pts. 10,967
• 6. LociOiling 87 pts. 10,950
• 7. MurloW 85 pts. 10,949
• 8. bertro 82 pts. 10,945
• 9. reefyrob 80 pts. 10,936
• 10. Timo van der Laan 78 pts. 10,926