1355: 100 Residue Monomer Design: Helix Restrictions

Closed since almost 9 years ago

Summary

• Created: March 18, 2017
• Expires: March 26, 2017 at 23:00 UTC
• Max points: 100

Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. Team South Africa 7 pts. 9,261
• 12. D001x Med Chem MOOC 5 pts. 8,485
• 13. :) 4 pts. 7,615
• 14. GUGITBIOTECH 3 pts. 7,598
• 15. Kotocycle 2 pts. 7,519
• 16. Eὕρηκα! Heureka! 1 pt. 7,355
• 17. DSN @ Home 1 pt. 7,145
• 18. xkcd 1 pt. 6,922
• 19. BIO257C 1 pt. 6,743
• 20. Team Schleswig-Holstein 1 pt. 6,324

Top soloists

• 11. Susume 75 pts. 10,922
• 12. pauldunn 73 pts. 10,883
• 13. eusair 71 pts. 10,882
• 14. actiasluna 69 pts. 10,865
• 15. fiendish_ghoul 67 pts. 10,862
• 16. ZeroLeak7 65 pts. 10,857
• 17. Bruno Kestemont 63 pts. 10,848
• 18. Vredeman 61 pts. 10,847
• 19. Glen B 59 pts. 10,836
• 20. kabubi 57 pts. 10,827