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1355: 100 Residue Monomer Design: Helix Restrictions

Closed since about 9 years ago

Intermediate Overall Design

Summary

Created
March 18, 2017
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 21. Russian team 1 pt. 4,093
  2. Avatar for Natural Abilities 22. Natural Abilities 1 pt. 3,959
  3. Avatar for Deleted group 23. Deleted group pts. 497
  4. Avatar for SciOne2017 24. SciOne2017 1 pt. 0
  5. Avatar for Window Group 25. Window Group 1 pt. 0
  1. Avatar for MadCat08 121. MadCat08 Lv 1 1 pt. 6,648
  2. Avatar for Jeremiah 10 122. Jeremiah 10 Lv 1 1 pt. 6,448
  3. Avatar for gondust 123. gondust Lv 1 1 pt. 6,442
  4. Avatar for MuckeMcFly 124. MuckeMcFly Lv 1 1 pt. 6,324
  5. Avatar for jamiexq 125. jamiexq Lv 1 1 pt. 6,145
  6. Avatar for Squirrely 126. Squirrely Lv 1 1 pt. 5,763
  7. Avatar for jbmkfm125 127. jbmkfm125 Lv 1 1 pt. 5,335
  8. Avatar for Jumbly 128. Jumbly Lv 1 1 pt. 4,694
  9. Avatar for Deleted player 129. Deleted player pts. 4,604
  10. Avatar for teraflop 130. teraflop Lv 1 1 pt. 4,350

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