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1355: 100 Residue Monomer Design: Helix Restrictions

Closed since about 9 years ago

Intermediate Intermediate Overall Overall Design Design

Summary

Created
March 18, 2017
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 21. Russian team 1 pt. 4,093
  2. Avatar for Natural Abilities 22. Natural Abilities 1 pt. 3,959
  3. Avatar for Deleted group 23. Deleted group pts. 497
  4. Avatar for SciOne2017 24. SciOne2017 1 pt. 0
  5. Avatar for Window Group 25. Window Group 1 pt. 0
  1. Avatar for ralan-nsk 131. ralan-nsk Lv 1 1 pt. 4,093
  2. Avatar for lamoille 132. lamoille Lv 1 1 pt. 4,007
  3. Avatar for Mr_Jolty 133. Mr_Jolty Lv 1 1 pt. 3,959
  4. Avatar for pooja chennupati 134. pooja chennupati Lv 1 1 pt. 3,955
  5. Avatar for Mydogisa Toelicker 135. Mydogisa Toelicker Lv 1 1 pt. 3,875
  6. Avatar for emdee314 136. emdee314 Lv 1 1 pt. 3,622
  7. Avatar for AO91 137. AO91 Lv 1 1 pt. 3,025
  8. Avatar for pulzang 138. pulzang Lv 1 1 pt. 1,542
  9. Avatar for JoJack 139. JoJack Lv 1 1 pt. 1,184
  10. Avatar for frostschutz 140. frostschutz Lv 1 1 pt. 651

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