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1355: 100 Residue Monomer Design: Helix Restrictions

Closed since about 9 years ago

Intermediate Overall Design

Summary

Created
March 18, 2017
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 21. Russian team 1 pt. 4,093
  2. Avatar for Natural Abilities 22. Natural Abilities 1 pt. 3,959
  3. Avatar for Deleted group 23. Deleted group pts. 497
  4. Avatar for SciOne2017 24. SciOne2017 1 pt. 0
  5. Avatar for Window Group 25. Window Group 1 pt. 0
  1. Avatar for Museka 31. Museka Lv 1 40 pts. 10,519
  2. Avatar for Anfinsen_slept_here 32. Anfinsen_slept_here Lv 1 39 pts. 10,505
  3. Avatar for crpainter 33. crpainter Lv 1 38 pts. 10,502
  4. Avatar for christioanchauvin 34. christioanchauvin Lv 1 36 pts. 10,489
  5. Avatar for johnmitch 35. johnmitch Lv 1 35 pts. 10,475
  6. Avatar for Mike Cassidy 36. Mike Cassidy Lv 1 34 pts. 10,388
  7. Avatar for isaksson 37. isaksson Lv 1 33 pts. 10,377
  8. Avatar for Bautho 38. Bautho Lv 1 32 pts. 10,370
  9. Avatar for hansvandenhof 39. hansvandenhof Lv 1 31 pts. 10,367
  10. Avatar for Hiro Protagonist 40. Hiro Protagonist Lv 1 30 pts. 10,329

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