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1355: 100 Residue Monomer Design: Helix Restrictions

Closed since about 9 years ago

Intermediate Overall Design

Summary

Created
March 18, 2017
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 21. Russian team 1 pt. 4,093
  2. Avatar for Natural Abilities 22. Natural Abilities 1 pt. 3,959
  3. Avatar for Deleted group 23. Deleted group pts. 497
  4. Avatar for SciOne2017 24. SciOne2017 1 pt. 0
  5. Avatar for Window Group 25. Window Group 1 pt. 0
  1. Avatar for NinjaGreg 61. NinjaGreg Lv 1 13 pts. 9,473
  2. Avatar for randomlil 62. randomlil Lv 1 13 pts. 9,442
  3. Avatar for karost 63. karost Lv 1 12 pts. 9,425
  4. Avatar for ViJay7019 64. ViJay7019 Lv 1 12 pts. 9,415
  5. Avatar for fishercat 65. fishercat Lv 1 11 pts. 9,334
  6. Avatar for rabamino12358 66. rabamino12358 Lv 1 11 pts. 9,330
  7. Avatar for Alistair69 67. Alistair69 Lv 1 10 pts. 9,318
  8. Avatar for dssb 68. dssb Lv 1 10 pts. 9,304
  9. Avatar for doctaven 69. doctaven Lv 1 10 pts. 9,261
  10. Avatar for Randolph_M_Snyder 70. Randolph_M_Snyder Lv 1 9 pts. 9,160

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