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1364: Variable Length Monomer Design: Helix Restrictions

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
April 10, 2017
Expires
Max points
100
Description

This design puzzle is meant to give players more freedom to adjust the length of their solutions. We've tuned the Residue Count Filter so that solutions of all different lengths should score competitively—that is, we expect a good 70-residue design to score just as well as a good 90-residue design. The starting structure includes 65 residues, but players may use up to 100. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 100 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."