Placeholder image of a protein
Icon representing a puzzle

1364: Variable Length Monomer Design: Helix Restrictions

Closed since almost 9 years ago

Intermediate Intermediate Overall Overall Design Design

Summary

Created
April 10, 2017
Expires
Max points
100
Description

This design puzzle is meant to give players more freedom to adjust the length of their solutions. We've tuned the Residue Count Filter so that solutions of all different lengths should score competitively—that is, we expect a good 70-residue design to score just as well as a good 90-residue design. The starting structure includes 65 residues, but players may use up to 100. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Richard Dawkins Foundation 21. Richard Dawkins Foundation 1 pt. 0
  1. Avatar for SeaGodling 121. SeaGodling Lv 1 1 pt. 2,374
  2. Avatar for corvuscorax 122. corvuscorax Lv 1 1 pt. 0
  3. Avatar for phi16 123. phi16 Lv 1 1 pt. 0
  4. Avatar for AeonFluff 124. AeonFluff Lv 1 1 pt. 0
  5. Avatar for pmdpmd 125. pmdpmd Lv 1 1 pt. 0
  6. Avatar for ManVsYard 126. ManVsYard Lv 1 1 pt. 0
  7. Avatar for cnhrcolemam 127. cnhrcolemam Lv 1 1 pt. 0
  8. Avatar for WBarme1234 128. WBarme1234 Lv 1 1 pt. 0
  9. Avatar for Formula350 129. Formula350 Lv 1 1 pt. 0
  10. Avatar for 01010011111 130. 01010011111 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 100 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."