1383: Medium Monomer Design

Closed since almost 9 years ago

Summary

• Created: May 24, 2017
• Expires: June 02, 2017 at 23:00 UTC
• Max points: 100

Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. Richard Dawkins Foundation 1 pt. 8,075
• 12. freefolder 1 pt. 7,829
• 13. Natural Abilities 1 pt. 4,892
• 14. DSN @ Home 1 pt. 3,832
• 15. xkcd 1 pt. 0
• 16. SETI.Germany 1 pt. 0
• 17. Deleted group pts. 0

Top soloists

• 31. fiendish_ghoul 28 pts. 10,131
• 32. isaksson 26 pts. 10,087
• 33. Anfinsen_slept_here 25 pts. 10,087
• 34. pvc78 24 pts. 10,072
• 35. christioanchauvin 23 pts. 10,057
• 36. tony46 22 pts. 10,052
• 37. Mike Cassidy 21 pts. 9,951
• 38. uihcv 20 pts. 9,946
• 39. caglar 19 pts. 9,945
• 40. mimi 18 pts. 9,859

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."