Placeholder image of a protein
Icon representing a puzzle

1383: Medium Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
May 24, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,507
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 73 pts. 10,486
  3. Avatar for Go Science 3. Go Science 52 pts. 10,467
  4. Avatar for Gargleblasters 4. Gargleblasters 36 pts. 10,400
  5. Avatar for Void Crushers 5. Void Crushers 24 pts. 10,388
  6. Avatar for Contenders 6. Contenders 16 pts. 10,311
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 10 pts. 10,219
  8. Avatar for HMT heritage 8. HMT heritage 6 pts. 9,403
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 4 pts. 8,902
  10. Avatar for Russian team 10. Russian team 2 pts. 8,083
  1. Avatar for fiendish_ghoul 31. fiendish_ghoul Lv 1 28 pts. 10,131
  2. Avatar for isaksson 32. isaksson Lv 1 26 pts. 10,087
  3. Avatar for Anfinsen_slept_here 33. Anfinsen_slept_here Lv 1 25 pts. 10,087
  4. Avatar for pvc78 34. pvc78 Lv 1 24 pts. 10,072
  5. Avatar for christioanchauvin 35. christioanchauvin Lv 1 23 pts. 10,057
  6. Avatar for tony46 36. tony46 Lv 1 22 pts. 10,052
  7. Avatar for Mike Cassidy 37. Mike Cassidy Lv 1 21 pts. 9,951
  8. Avatar for uihcv 38. uihcv Lv 1 20 pts. 9,946
  9. Avatar for caglar 39. caglar Lv 1 19 pts. 9,945
  10. Avatar for mimi 40. mimi Lv 1 18 pts. 9,859

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."