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1383: Medium Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary


Created
May 24, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  2. Avatar for dbuske 102. dbuske Lv 1 1 pt. 7,033
  3. Avatar for UTCeanFolder 103. UTCeanFolder Lv 1 1 pt. 6,995
  4. Avatar for DScott 104. DScott Lv 1 1 pt. 6,974
  5. Avatar for kamilko 105. kamilko Lv 1 1 pt. 6,948
  6. Avatar for SAzelo 106. SAzelo Lv 1 1 pt. 6,860
  7. Avatar for alwen 107. alwen Lv 1 1 pt. 6,221
  8. Avatar for DestinVantine 108. DestinVantine Lv 1 1 pt. 6,026
  9. Avatar for leannerikicheever 109. leannerikicheever Lv 1 1 pt. 4,965
  10. Avatar for Soggy Doglog 110. Soggy Doglog Lv 1 1 pt. 4,940

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."