Placeholder image of a protein
Icon representing a puzzle

1383: Medium Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
May 24, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,507
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 73 pts. 10,486
  3. Avatar for Go Science 3. Go Science 52 pts. 10,467
  4. Avatar for Gargleblasters 4. Gargleblasters 36 pts. 10,400
  5. Avatar for Void Crushers 5. Void Crushers 24 pts. 10,388
  6. Avatar for Contenders 6. Contenders 16 pts. 10,311
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 10 pts. 10,219
  8. Avatar for HMT heritage 8. HMT heritage 6 pts. 9,403
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 4 pts. 8,902
  10. Avatar for Russian team 10. Russian team 2 pts. 8,083
  1. Avatar for harvardman 71. harvardman Lv 1 3 pts. 8,563
  2. Avatar for bcre8tvv 72. bcre8tvv Lv 1 3 pts. 8,529
  3. Avatar for froggs554 73. froggs554 Lv 1 2 pts. 8,524
  4. Avatar for mitarcher 74. mitarcher Lv 1 2 pts. 8,474
  5. Avatar for jinhd6 75. jinhd6 Lv 1 2 pts. 8,367
  6. Avatar for Deleted player 76. Deleted player pts. 8,223
  7. Avatar for skracked 77. skracked Lv 1 2 pts. 8,201
  8. Avatar for maman 78. maman Lv 1 2 pts. 8,199
  9. Avatar for Superphosphate 79. Superphosphate Lv 1 2 pts. 8,135
  10. Avatar for ralan-nsk 80. ralan-nsk Lv 1 1 pt. 8,083

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."