1435: Extra Large Monomer Design

Closed since over 8 years ago

Summary

• Created: September 29, 2017
• Expires: October 06, 2017 at 23:00 UTC
• Max points: 100

Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Anthropic Dreams 100 pts. 11,064
• 2. Gargleblasters 73 pts. 11,057
• 3. Beta Folders 52 pts. 10,851
• 4. Go Science 36 pts. 10,811
• 5. Contenders 24 pts. 10,808
• 6. Void Crushers 16 pts. 10,747
• 7. L'Alliance Francophone 10 pts. 10,665
• 8. Marvin's bunch 6 pts. 10,557
• 9. :) 4 pts. 8,851
• 10. Alpha Rays 2 pts. 8,614

Top soloists

• 1. markm457 100 pts. 11,062
• 2. Enzyme 97 pts. 11,057
• 3. matosfran 93 pts. 10,851
• 4. LociOiling 90 pts. 10,850
• 5. ZeroLeak7 86 pts. 10,811
• 6. crpainter 83 pts. 10,808
• 7. actiasluna 80 pts. 10,807
• 8. Susume 76 pts. 10,760
• 9. Timo van der Laan 73 pts. 10,747
• 10. Skippysk8s 71 pts. 10,723

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

[Skippysk8s]

I'm fine with points in filters doing whatever they do. But lower penalty for extra segments means I should have maxed out the segment count.
I'd love to understand the science goal. Maybe we can align that with the folds and produce something more useful
Skippy