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1435: Extra Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
September 29, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Biochem-AD17 11. Biochem-AD17 1 pt. 8,453
  2. Avatar for Team South Africa 12. Team South Africa 1 pt. 8,254
  3. Avatar for Richard Dawkins Foundation 13. Richard Dawkins Foundation 1 pt. 8,097
  4. Avatar for Deleted group 14. Deleted group pts. 7,114
  5. Avatar for Natural Abilities 15. Natural Abilities 1 pt. 4,648
  6. Avatar for Rice Biochemistry 16. Rice Biochemistry 1 pt. 0
  7. Avatar for Window Group 17. Window Group 1 pt. 0
  1. Avatar for Alex Amino 81. Alex Amino Lv 1 1 pt. 7,461
  2. Avatar for DScott 82. DScott Lv 1 1 pt. 7,453
  3. Avatar for pandapharmd 83. pandapharmd Lv 1 1 pt. 7,441
  4. Avatar for Fowardint 84. Fowardint Lv 1 1 pt. 7,347
  5. Avatar for LOGOLOZ 85. LOGOLOZ Lv 1 1 pt. 7,146
  6. Avatar for applx 86. applx Lv 1 1 pt. 7,131
  7. Avatar for TotallyEvergreen 87. TotallyEvergreen Lv 1 1 pt. 7,122
  8. Avatar for Sofiya Haiduk 88. Sofiya Haiduk Lv 1 1 pt. 7,121
  9. Avatar for HUCKCHR 89. HUCKCHR Lv 1 1 pt. 7,114
  10. Avatar for Nobody541 90. Nobody541 Lv 1 1 pt. 7,105

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

Skippysk8s Lv 1

I'm fine with points in filters doing whatever they do. But lower penalty for extra segments means I should have maxed out the segment count.
I'd love to understand the science goal. Maybe we can align that with the folds and produce something more useful
Skippy