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1437: Small Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
October 06, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,225
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  1. Avatar for toshiue 31. toshiue Lv 1 33 pts. 9,847
  2. Avatar for Vinara 32. Vinara Lv 1 31 pts. 9,845
  3. Avatar for gurch 33. gurch Lv 1 30 pts. 9,780
  4. Avatar for dizzywings 34. dizzywings Lv 1 29 pts. 9,771
  5. Avatar for stomjoh 35. stomjoh Lv 1 28 pts. 9,710
  6. Avatar for christioanchauvin 36. christioanchauvin Lv 1 26 pts. 9,648
  7. Avatar for reefyrob 37. reefyrob Lv 1 25 pts. 9,625
  8. Avatar for georg137 38. georg137 Lv 1 24 pts. 9,587
  9. Avatar for Deleted player 39. Deleted player pts. 9,538
  10. Avatar for alcor29 40. alcor29 Lv 1 22 pts. 9,438

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."