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1457: Extra Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
December 04, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Gargleblasters
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  1. Avatar for toshiue 41. toshiue Lv 1 20 pts. 9,686
  2. Avatar for Cagdason 42. Cagdason Lv 1 19 pts. 9,674
  3. Avatar for georg137 43. georg137 Lv 1 18 pts. 9,628
  4. Avatar for Deleted player 44. Deleted player pts. 9,526
  5. Avatar for alcor29 45. alcor29 Lv 1 16 pts. 9,440
  6. Avatar for smilingone 46. smilingone Lv 1 16 pts. 9,435
  7. Avatar for O Seki To 47. O Seki To Lv 1 15 pts. 9,390
  8. Avatar for diamonddays 48. diamonddays Lv 1 14 pts. 9,162
  9. Avatar for katling 49. katling Lv 1 13 pts. 9,116
  10. Avatar for jobo0502 50. jobo0502 Lv 1 13 pts. 9,024

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."